Agradecimentos: We are grateful to CAPES, FAEPEX-UNICAMP, FAPESP and CNPq for scholarships and financial support, CNPq by authorization for access of samples from the Brazilian genetic heritage (process 010087/2012-5), Clarisse B. Poliquesi, at Museu Botânico Municipal de Curitiba, for collection...

Agradecimentos: We are grateful to CAPES, FAEPEX-UNICAMP, FAPESP and CNPq for scholarships and financial support, CNPq by authorization for access of samples from the Brazilian genetic heritage (process 010087/2012-5), Clarisse B. Poliquesi, at Museu Botânico Municipal de Curitiba, for collection and identification of the plant, and A. A. Stefanello for English revision

Abstract: Chemical investigation of Sinningia warmingii (Gesneriaceae) tubers lead to the isolation of two new dimeric naphthoquinone derivatives, named warmingiins A and B, besides six known compounds, aggregatin E, aggregatin F, tectoquinone, halleridone, cleroindicin B, and cornoside. All...

Abstract: Chemical investigation of Sinningia warmingii (Gesneriaceae) tubers lead to the isolation of two new dimeric naphthoquinone derivatives, named warmingiins A and B, besides six known compounds, aggregatin E, aggregatin F, tectoquinone, halleridone, cleroindicin B, and cornoside. All compounds were identified by spectroscopic analysis, mainly nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison with the literature. The structure of the warmingiin A, which is an artifact of warmingiin B, was confirmed by X-ray diffraction analysis. Antimicrobial activity of the ethanolic extract and fractions of S. warmingii was evaluated against Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, C. dubliniensis, C. glabrata and C. parapsilosis. All samples were inactive

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

010087/2012-5

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

Aberto