Agradecimentos: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP): Grant/award number: 2018/23,428-0 | Recipient: JBCC; Conselho nacional de desenvolvimento científico e tecnológico (CNPq): Grant/award number: 302,535/2018-7 | Recipient: JBCC; Conselho nacional de desenvolvimento...

Agradecimentos: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP): Grant/award number: 2018/23,428-0 | Recipient: JBCC; Conselho nacional de desenvolvimento científico e tecnológico (CNPq): Grant/award number: 302,535/2018-7 | Recipient: JBCC; Conselho nacional de desenvolvimento científico e tecnológico (CNPq): Grant/award number: 140,596/2019-4 | Recipient: MNS. We thank the staff of Life Sciences Core facility (LaCTAD), for the adypokines and cytokines analyses

Abstract: Background & aims: The use of computerized tomography to opportunistically assess body composition has highlighted abnormalities such as low muscle mass and high adiposity may be hidden conditions in cancer patients. However, the role of skeletal muscle (SM), subcutaneous (SAT) and...

Abstract: Background & aims: The use of computerized tomography to opportunistically assess body composition has highlighted abnormalities such as low muscle mass and high adiposity may be hidden conditions in cancer patients. However, the role of skeletal muscle (SM), subcutaneous (SAT) and visceral (VAT) adipose tissue glucose uptake measured by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)-CT on patient prognostication is unclear. Methods: Patients with multiple myeloma (MM) with satisfactory image frame for assessing body composition and for semi-quantification of SM, SAT and VAT glucose uptakes were included. Plasmatic pro-inflammatory cytokine and adipokine levels were measured. Results: High VAT mean standardized uptake value (SUV) at baseline was associated with shorter eventfree survival (EFS) (hazard ratio [HR]: 7.89; 95% confidence interval [CI], 1.58-39.30; P = 0.012) and overall survival (OS) (HR, 15.24; 95% CI, 2.69-86.30; P = 0.002) among patients with newly diagnosed MM, even after adjustment for covariates. The highest tertile of VAT SUV was significantly correlated with worse MM-EFS (HR for the highest vs the lowest tertile 3.71; 95% CI, 1.22-10.56; Ptrend = 0.035) and mortality (HR, 4.41; 95% CI, 1.28-12.77; Ptrend = 0.019). Notably, patients with higher VAT SUV presented with lower VAT area, VAT index, higher SAT SUV, and higher number of individuals with visceral obesity (all P < 0.01). Additionally, we found a negative correlation between VAT mean SUV with leptin (R2 = 0.20, P = 0.003); no correlations were detected between VAT mean SUV and resistin, tumor necrosis factor (TNF) or interleukin (IL)-6. Conclusions: Functional VAT activity estimated by 18F-FDG PET-CT is a relevant prognostic factor in MM patients, specifically, a higher VAT SUV might be an early biomarker of cancer cachexia in these patients

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2018/23428-0

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

302535/2018-7; 140596/2019-4

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