[en] A variety of poly(epsilon-caprolactone)-grafted dextran copolymers were synthesized with a controlled architecture through a three-step procedure: partial protection of the dextran hydroxyl groups by silylation, ring-opening polymerization of epsilon-caprolactone initiated from remaining free hydroxyl groups on partially silylated dextran, and silyl ether deprotection under mild conditions. The potential of these amphiphilic grafted copolymers as surfactants was investigated by water/toluene interfacial tension measurements. Since each copolymer showed noticeable surfactant properties, their ability to form 'surfactant-free' nanoparticles was evaluated using the nanoprecipitation method. It was found that remarkably stable core (polyester) - shell (polysaccharide) nanoparticles with a mean diameter around 200 nm were formed.
Disciplines :
Chemistry
Author, co-author :
Ydens, I.
Degée, Philippe
Nouvel, C.
Dellacherie, E.
Six, J.-L.
Dubois, Philippe ; Université de Mons > Faculté des Sciences > Matériaux Polymères et Composites
Language :
English
Title :
'Surfactant-free' stable nanoparticles from biodegradable and amphiphilic poly(e-caprolactone)-grafted dextran copolymers
Publication date :
05 July 2005
Journal title :
e-Polymers
Publisher :
European Polymer Federation, France
Volume :
046
Pages :
1-11
Peer reviewed :
Peer reviewed
Research unit :
S816 - Matériaux Polymères et Composites
Research institute :
R400 - Institut de Recherche en Science et Ingénierie des Matériaux
Commentary :
ISSN: 1618-7229
Lecture en ligne: http://www.e-polymers.org/journal/papers/dubois_050705.pdf
