[en] MRI; [en] Positive contrast; [en] Iron oxide nanoparticles
Abstract :
[en] Superparamagnetic iron oxide nanoparticles (SPM particles) are widely used in MRI as negative contrast agents. Their detection is sometimes rendered difficult because negative contrast can be caused by different artifacts. To overcome this problem, MRI protocols achieving positive contrast specific to SPM particles were developed such as the ON-Resonance Saturation (ONRS) sequence. The aim of this study is to achieve a bottom-up study of the ONRS sequence by an understanding of the physical mechanisms leading to positive contrast. A complete theoretical modeling, a novel numerical simulation approach and experiments on agarose gel phantoms on a 11.7T MRI system were carried out to study and understand the contrast induced by ONRS. The influence of the particle properties and concentration - as well as the effect of the sequence parameters on the contrast - were investigated. It was observed that theory and experiments were in strong agreement. The tools developed in this work allowed to predict the optimal parameters leading to the maximum contrast. For example, particles presenting a low transverse relaxivity can provide an interesting positive contrast after optimization of their concentration in the sample.
Disciplines :
Radiology, nuclear medicine & imaging Physics
Author, co-author :
Delangre, Sébastien ; Université de Mons > Faculté de Médecine et de Pharmacie > Physique biomédicale
Vuong, Quoc Lam ; Université de Mons > Faculté de Médecine et de Pharmacie > Physique biomédicale
Henrard, Daniel ; Université de Mons > Faculté de Médecine et de Pharmacie > Physique biomédicale
Po, Chrystelle
Gallez, Bernard
Gossuin, Yves ; Université de Mons > Faculté de Médecine et de Pharmacie > Service de Physique biomédicale
Language :
English
Title :
Theoretical and experimental study of ON-Resonance Saturation, an MRI sequence for Positive Contrast with Superparamagnetic Nanoparticles
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