Agents de contraste en IRM : approche théorique des mécanismes de relaxation

De Marco, G.; Roch, Alain; Perreti, I.; Gossuin, Yves; Lehman, P.; Menuel, C.; Vallée, J.N.; Muller, Robert

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Article (Scientific journals)

Agents de contraste en IRM : approche théorique des mécanismes de relaxation

De Marco, G.; Roch, Alain; Perreti, I. et al.

2006 • In Médecine Nucléaire: Imagerie Fonctionnelle et Métabolique, 30, p. 645-658

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Abstract :

[fr] Cet article reprend les concepts théoriques et résume les modèles mathématiques à partir desquels les mécanismes de relaxation des agents de contraste IRM ont été décrits et mis en lumière depuis près d'un demi-siècle. Dans un premier volet, les propriétés physico-chimiques et les mécanismes relaxométriques de sphère interne et externe des molécules paramagnétiques sont présentés, ainsi que ceux des nanoparticules superparamagnétiques. Les différents modèles de sphère externe, développés jusqu'à ce jour, sont passés en revue et présentés en fonction de la taille des nanoparticules. Ces modèles analytiques permettent de décrire parfaitement ces entités magnétiques quelles que soient leur taille et leur nature. Ainsi, ces travaux fondamentaux permettent de mieux comprendre les mécanismes d'action des agents de contraste in vivo et de poser les bases d'une caractérisation tissulaire en IRM.

Disciplines :

Radiology, nuclear medicine & imaging
Biochemistry, biophysics & molecular biology
Chemistry

Author, co-author :

De Marco, G.

Roch, Alain

Perreti, I.

Gossuin, Yves ; Université de Mons > Faculté de Médecine et de Pharmacie > Biomathématiques

Lehman, P.

Menuel, C.

Vallée, J.N.

Muller, Robert ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Language :

French

Title :

Agents de contraste en IRM : approche théorique des mécanismes de relaxation

Publication date :

01 January 2006

Journal title :

Médecine Nucléaire: Imagerie Fonctionnelle et Métabolique

ISSN :

0928-1258

Publisher :

Elsevier Masson, Paris, France

Volume :

Pages :

645-658

Peer reviewed :

Peer reviewed

Research unit :

M108 - Chimie générale, organique et biomédicale
M104 - Physique biomédicale

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