Lechien JR, Akst LM, Hamdan AL, et al. Evaluation and management of laryngopharyngeal reflux disease: state of the art review. Otolaryngol Head Neck Surg 2019;160:762–782.
Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope 2004;114:2129–2134.
Johnston N, Wells CW, Samuels TL, Blumin JH. Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells. Ann Otol Rhinol Laryngol 2009;118:677–685.
Potluri S, Friedenberg F, Parkman HP, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci 2003;48:1813–1817.
Wang J, Zhao Y, Ren J, Xu Y. Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis. Eur Arch Otorhinolaryngol 2018;275:671–678.
Calvo-Henríquez C, Ruano-Ravina A, Vaamonde P, Martínez-Capoccioni G, Martín-Martín C. Is pepsin a reliable marker of laryngopharyngeal reflux? A systematic review. Otolaryngol Head Neck Surg 2017;157:385–391.
Lechien JR, Bobin F, Muls V, et al. Patients with acid, high-fat and low-protein diet have higher laryngopharyngeal reflux episodes at the impedance-pH monitoring. Eur Arch Otorhinolaryngol 2020;277:511–520.
Hoppo T, Komatsu Y, Nieponice A, Schrenker J, Jobe BA. Toward an improved understanding of isolated upright reflux: positional effects on the lower esophageal sphincter in patients with symptoms of gastroesophageal reflux. World J Surg 2012;36:1623–1631.
Bobin F, Journe F, Lechien JR. Saliva pepsin level of laryngopharyngeal reflux patients is not correlated with reflux episodes. Laryngoscope 2020;130:1278–1281.
Lechien JR, Bobin F, Muls V, et al. Validity and reliability of the reflux symptom score. Laryngoscope 2020;130:E98–E107.
Lechien JR, Rodriguez Ruiz A, Dequanter D, et al. Validity and reliability of the reflux sign assessment. Ann Otol Rhinol Laryngol 2020;129:313–325.
Lechien JR, Bobin F, Mouawad F, et al. Development of a score assessing the refluxogenic potential of diet of patients with laryngopharyngeal reflux. Eur Arch Otorhinolaryngol 2019;276:3389–3404.
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900–1920; quiz 1943.
Koufman JA. Low-acid diet for recalcitrant laryngopharyngeal reflux: therapeutic benefits and their implications. Ann Otol Rhinol Laryngol 2011;120:281–287.
Lechien JR, Huet K, Khalife M, et al. Alkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: our experience on 65 patients. Clin Otolaryngol 2019;44:379–384.
Min C, Park B, Sim S, Choi HG. Dietary modification for laryngopharyngeal reflux: systematic review. J Laryngol Otol 2019;133:80–86.
Lechien JR, Bobin F, Dapri G, et al. Hypopharyngeal-Esophageal Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients. Laryngoscope. 2020. https://org.doi/10.1002/lary.28736
Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101:1–78.
Jung AR, Kwon OE, Park JM, et al. Association between pepsin in the saliva and the subjective symptoms in patients with Laryngopharyngeal reflux. J Voice 2019;33:150–154.
Lechien JR, Allen J, Mouawad F, et al. Do laryngologists and general otolaryngologists manage laryngopharyngeal reflux differently [published online January 8, 2020]? Laryngoscope. https://doi.org/10.1002/lary.28484.
