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Binding of the human glucocorticoid receptor to defined regions in the human growth hormone and placental lactogen genes
Eliard, PH; Marchand, MJ; Rousseau, GG et al.
1985In DNA, 4 (6), p. 409-417
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Abstract :
[en] An in vitro competition assay was used to investigate whether binding sites for the human glucocorticoid receptor occur in the human genes for growth hormone (hGH) and placental lactogen (chorionic somatomammotropin, hCS). These genes display 95% sequence homology. Two receptor-binding regions were found in the hGH gene, one of which is located within 290 bp upstream, and one within 251 bp downstream from the transcription initiation site. Two binding regions homologous to those in the hGH gene were found in the hCS gene. The receptor-binding DNA fragment from the structural part of the genes, but not that from their promoter area, contained a sequence homologous to a 15-bp consensus sequence proposed earlier for the glucocorticoid receptor binding site. It is unlikely that the putative difference in glucocorticoid sensitivity between the hGH and hCS genes is accounted for by major differences in glucocorticoid receptor binding pattern.
Disciplines :
Biotechnology
Author, co-author :
Eliard, PH
Marchand, MJ
Rousseau, GG
Formstecher, P
Mathy-Hartert, M
Belayew, Alexandra 
Martial, JA
Language :
English
Title :
Binding of the human glucocorticoid receptor to defined regions in the human growth hormone and placental lactogen genes
Publication date :
12 December 1985
Journal title :
DNA
ISSN :
0198-0238
Publisher :
Mary Ann Liebert, United States - New York
Volume :
4
Issue :
6
Pages :
409-417
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi UMONS :
since 12 July 2013

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