Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover

Colombaro, V; Jado, I; Decleves, Anne-Emilie; Voisin, V; Giordano, L; Habsch, I; Flamion, B; Caron, N

doi:10.1016/j.acthis.2014.11.007

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Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover

Colombaro, V; Jado, I; Decleves, Anne-Emilie et al.

2015 • In Acta Histochemica, 117 (1), p. 83-91

Peer Reviewed verified by ORBi

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https://hdl.handle.net/20.500.12907/8595

DOI
10.1016/j.acthis.2014.11.007

PubMed
25468725

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Abstract :

[en] Abstract Hyaluronidase 1 (HYAL1) and hyaluronidase 2 (HYAL2) are the major hyaluronidases acting synergistically to degrade hyaluronan (HA). In the kidney, HA is distributed heterogeneously. Our goal was to determine the consequences of a lack of either HYAL1 or HYAL2 (using specific knockout mice) on renal function and on renal HA accumulation. Experiments were performed in Hyal1(-/-) and Hyal2(-/-) mice and in their wild-type controls. HA concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of HYAL1, HYAL2 and the 3 main HA synthases were evaluated by quantitative RT-PCR. Results: Kidney function was not impaired in the knockout mice but they displayed elevated HA concentrations in the plasma and in the kidney. Hyal1(-/-) mice presented an accumulation of HA inside the proximal tubular cells whereas Hyal2(-/-) mice showed HA accumulation in the interstitial space. In the cortex and in the outer medulla, HYAL1 mRNA expression was up-regulated in Hyal2(-/-) mice. From our study we conclude that somatic hyaluronidases are not required for renal function. However, HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions.

Research center :

UMHAP - Centre de Recherche UMONS-Ambroise Paré

Disciplines :

Endocrinology, metabolism & nutrition
General & internal medicine
Immunology & infectious disease
Urology & nephrology

Author, co-author :

Colombaro, V

Jado, I

Decleves, Anne-Emilie

Voisin, V

Giordano, L

Habsch, I

Flamion, B

Caron, N

Language :

English

Title :

Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover

Publication date :

01 January 2015

Journal title :

Acta Histochemica

ISSN :

0065-1281

Publisher :

Elsevier, Netherlands

Volume :

117

Issue :

Pages :

83-91

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

M122 - Biochimie métabolique et moléculaire

Research institute :

R550 - Institut des Sciences et Technologies de la Santé

Available on ORBi UMONS :

since 07 December 2015

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