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Article (Scientific journals)
MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
Zhan, Y; Guo, J; Yang, W et al.
2017In Journal of Clinical Investigation, 127 (11), p. 4179-4192
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Keywords :
High Energy Physics - Experiment
Abstract :
The charged particle transverse momentum (pT) spectra are presented for pp collisions at sqrt(s)=0.9 and 7 TeV. The data samples were collected with the CMS detector at the LHC and correspond to integrated luminosities of 231 inverse microbarns and 2.96 inverse picobarns, respectively. Calorimeter-based high-transverse-energy triggers are employed to enhance the statistical reach of the high-pT measurements. The results are compared with both leading-order QCD and with an empirical scaling of measurements at different collision energies using the scaling variable xT = 2 pT/sqrt(s) over the pT range up to 200 GeV/c. Using a combination of xT scaling and direct interpolation at fixed pT, a reference transverse momentum spectrum at sqrt(s)=2.76 TeV is constructed, which can be used for studying high-pT particle suppression in the dense QCD medium produced in heavy-ion collisions at that centre-of-mass energy.
Disciplines :
Education & instruction
Author, co-author :
Zhan, Y
Guo, J
Yang, W
Goncalves, C
Rzymski, T
Dreas, A
Zylkjewicz, E
Mikulski, M
Brzózka, K
Golas, A
Kong, Y
Ma, M
Huang, F
Huor, B
Guo, Q
Da Silva, SD
Torres, J
Cai, Y
Topisirovic, I
Su, J
Bijian, K
Alaoui-Jamali, MA
Huang, S
Journe, Fabrice  ;  Université de Mons > Faculté de Médecine et de Pharmacie > Service d'Anatomie humaine et Oncologie expérimentale
Ghanem, Ghanem
Miller, WH Jr
Del Rincon, SV
More authors (17 more) Less
Language :
English
Title :
MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
Publication date :
01 November 2017
Journal title :
Journal of Clinical Investigation
ISSN :
0021-9738
Publisher :
American Society for Clinical Investigation, United States - Michigan
Volume :
127
Issue :
11
Pages :
4179-4192
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
M112 - Anatomie humaine et Oncologie expérimentale
Research institute :
R550 - Institut des Sciences et Technologies de la Santé
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since 23 January 2018

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