Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Zandawala, Meet; Moghul, Ismail; Alfonso Yanez Guerra, Luis; Delroisse, Jérôme; Abylkassimova, Nikara; Hugall, Andrew F.; O'Hara, Timothy D.; Elphick, Maurice R.

doi:10.1098/rsob.170129

Article (Scientific journals)

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Zandawala, Meet; Moghul, Ismail; Alfonso Yanez Guerra, Luis et al.

2017 • In Open Biology, 7, p. 170129

Peer reviewed

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https://hdl.handle.net/20.500.12907/9333

DOI
10.1098/rsob.170129

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28878039

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Abstract :

[en] Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae, Amphiura filiformis and Ophiopsila aranea, has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata. Representatives of over 30 bilaterian neuropeptide precursor families were identified, some of which occur as paralogues. Furthermore, homologues of endothelin/CCHamide, eclosion hormone, neuropeptide-F/Y and nucleobinin/nesfatin were discovered here in a deuterostome/echinoderm for the first time. The majority of ophiuroid neuropeptide precursors contain a single copy of a neuropeptide, but several precursors comprise multiple copies of identical or non-identical, but structurally related, neuropeptides. Here, we performed an unprecedented investigation of the evolution of neuropeptide copy number over a period of approximately 270 Myr by analysing sequence data from over 50 ophiuroid species, with reference to a robust phylogeny. Our analysis indicates that the composition of neuropeptide 'cocktails' is functionally important, but with plasticity over long evolutionary time scales.

Research center :

BIOSYS - Biosys

Disciplines :

Architecture
Biotechnology
Phytobiology (plant sciences, forestry, mycology...)
Zoology

Author, co-author :

Zandawala, Meet

Moghul, Ismail

Alfonso Yanez Guerra, Luis

Delroisse, Jérôme ; Université de Mons > Faculté des Sciences > Biologie des Organismes Marins et Biomimétisme

Abylkassimova, Nikara

Hugall, Andrew F.

O'Hara, Timothy D.

Elphick, Maurice R.

Language :

English

Title :

Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms

Publication date :

01 September 2017

Journal title :

Open Biology

Publisher :

The Royal Society, United Kingdom

Volume :

Pages :

170129

Peer reviewed :

Peer reviewed

Research unit :

S864 - Biologie des Organismes Marins et Biomimétisme

Research institute :

R100 - Institut des Biosciences

Available on ORBi UMONS :

since 16 July 2018

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