Antimicrobial effects of positively charged, conductive electrospun polymer fibers
Authors
Bhattacharya, Somdatta
Kim, Domyoung
Gopal, Sneha
Tice, Aaron
Lang, Kening
Dordick, Jonathan S.
Plawsky, Joel L., 1957-
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2020-11-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Antimicrobial effects of positively charged, conductive electrospun polymer fibers, S. Bhattacharya, D. Kim, S. Gopal, A. Tice, K. Lang, J. S. Dordick, J. L. Plawsky, R. J. Linhardt, Materials Science & Engineering C, 116 ,111247, 2020.
Abstract
In recent years, electrospun polymer fibers have gained attention for various antibacterial applications. In this work, the effect of positively charged polymer fiber mats as antibacterial gauze is studied using electrospun poly(caprolactone) and polyaniline nanofibers. Chloroxylenol, an established anti-microbial agent is used for the first time as a secondary dopant to polyaniline during the electrospinning process to make the surface of the polyaniline fiber positively charged. Both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli are used to investigate the antibacterial activity of the positively charged and uncharged polymer surfaces. The results surprisingly show that the polyaniline surface can inhibit the growth of both bacteria even when chloroxylenol is used below its minimum inhibitory concentration. This study provides new insights allowing the better understanding of dopant-based, intrinsically conducting polymer surfaces for use as antibacterial fiber mats.
Description
Materials Science & Engineering C, 116 ,111247
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Elsevier
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Materials Science and Engineering C
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
Materials Science and Engineering C
https://harc.rpi.edu/
Access
A full text version is available in DSpace@RPI