Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray
Authors
Yang, Jianhong
Hsieh, Po Hung
Liu, Xinyue
Zhou, Wen
Zhang, Xing
Zhao, Jing
Xu, Yongmei
Zhang, Fuming
Linhardt, Robert J.
Liu, Jian
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2017-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Construction and Characterization of Heparan Sulfate Heptasaccharide Microarray, J. Yang, P.-H.Hsieh, X. Liu, W. Zhou, X. Zhang, F. Zhang, R. J. Linhardt, J. Liu, Chemical Communications, 53, 1743-1746, 2017.
Abstract
A targeted heptasaccharide library was synthesised to prepare a heparan sulphate (HS) microarray. The array was probed with two glycan-binding proteins, HS 3-O-sulphotransferase 1 and antithrombin, demonstrating the binding selectivity between HS and proteins. The HS microarray technique will accelerate the understanding of the structure and function relationships of HS.
Description
Chemical Communications, 53, 1743-1746
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Chemical Communications
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
Chemical Communications
https://harc.rpi.edu/
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