神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/0100477385
このアイテムのアクセス数:
41
件
(
2024-06-04
01:54 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
0100477385 (fulltext)
pdf
1.82 MB
43
メタデータ
ファイル出力
メタデータID
0100477385
アクセス権
open access
出版タイプ
Version of Record
タイトル
IgE receptor responsiveness of basophils in chronic inducible urticaria
著者
Mizuno, Mayuko ; Oda, Yoshiko ; Imamura, Shinya ; Washio, Ken ; Fukumoto, Takeshi ; Fukunaga, Atsushi
著者名
Mizuno, Mayuko
著者ID
A2852
研究者ID
1000090874082
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=21096bf9ecf9c05d520e17560c007669
著者名
Oda, Yoshiko
織田, 好子
オダ, ヨシコ
所属機関名
医学研究科
著者ID
A3241
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=d8207ec2cb0df3fa520e17560c007669
著者名
Imamura, Shinya
今村, 真也
イマムラ, シンヤ
所属機関名
医学部附属病院
著者ID
A2357
研究者ID
1000080770388
著者名
Washio, Ken
鷲尾, 健
ワシオ, ケン
所属機関名
医学部附属病院
著者ID
A0865
研究者ID
1000080778770
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=d16c4a96a87bb48a520e17560c007669
著者名
Fukumoto, Takeshi
福本, 毅
フクモト, タケシ
所属機関名
医学部附属病院
著者ID
A0799
研究者ID
1000010467649
著者名
Fukunaga, Atsushi
福永, 淳
フクナガ, アツシ
収録物名
Frontiers in Immunology
巻(号)
13
ページ
995596
出版者
Frontiers Media
刊行日
2022-09-23
公開日
2022-11-07
抄録
Introduction: Chronic inducible urticaria (CIndU) is a subgroup of chronic urticaria induced by a specific stimulus. We evaluated basophil characteristics in patients with CIndU and compared with those in patients with chronic spontaneous urticaria (CSU) and healthy controls (HCs). Methods: Blood was collected from patients, and a basophil activation test (BAT) was performed. Basophil responsiveness and surface marker expression in patients with CIndU were compared with those in patients with CSU and HCs. For some patients with CIndU, blood was collected before and after wheals were induced. In these cases, we compared the responsiveness of basophils before and after the appearance of wheals. Result: HCs (n=23) and patients with CIndU (n=24) or CSU (n=38) were enrolled in the study. The degree of basophil activation at steady state in patients with CIndU was higher than in HCs. Basophil responsiveness via high-affinity IgE receptor (FcϵRI) stimulation with anti-IgE or anti-FcϵRI antibody in patients with CIndU was equivalent to that in HCs, and higher than that in patients with CSU. No abnormalities in IgE and FcϵRI expressions on the surface of basophils in patients with CIndU were observed. When we induced wheals in some patients with CIndU and performed a BAT before and after the appearance of wheals, no significant changes were found. Conclusion: Peripheral blood basophils in CIndU were slightly activated at steady state, but no abnormalities in basophil responsiveness. In future, a higher number of cases should be enrolled to confirm the role of basophils and refine therapeutic targets for CIndU.
キーワード
chronic inducible urticaria
chronic spontaneous urticaria
basophil activation test
anti-IgE-induced histamine release
responsiveness of basophils via high-affinity IgE receptor
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2022 Mizuno, Oda, Imamura, Washio, Fukumoto and Fukunaga.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1664-3224
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.3389/fimmu.2022.995596
ホームへ戻る