神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/0100479045
このアイテムのアクセス数:
44
件
(
2024-06-02
14:07 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
0100479045 (fulltext)
pdf
662 KB
29
メタデータ
ファイル出力
メタデータID
0100479045
アクセス権
open access
出版タイプ
Version of Record
タイトル
Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127
著者
Moriya, Yuki ; Kasahara, Yoshiyuki ; Shimada, Masafumi ; Sakakibara, Yasufumi ; Fujii, Hideaki ; Nagase, Hiroshi ; Ide, Soichiro ; Ikeda, Kazutaka ; Hall, F. Scott ; Uhl, George R. ; Sora, Ichiro
著者名
Moriya, Yuki
著者名
Kasahara, Yoshiyuki
著者名
Shimada, Masafumi
著者名
Sakakibara, Yasufumi
著者名
Fujii, Hideaki
著者名
Nagase, Hiroshi
著者名
Ide, Soichiro
著者名
Ikeda, Kazutaka
著者名
Hall, F. Scott
著者名
Uhl, George R.
著者ID
A0074
研究者ID
1000040322713
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=ba1d67a1a7b786cc520e17560c007669
著者名
Sora, Ichiro
曽良, 一郎
ソラ, イチロウ
所属機関名
医学研究科
収録物名
Journal of Pharmacological Sciences
巻(号)
151(3)
ページ
135-141
出版者
Elsevier B.V.
刊行日
2023-03
公開日
2023-03-02
抄録
Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lower stress response compared with wildtype (WT) mice. Moreover, DOP agonists have been shown to exert antidepressant-like effects in numerous animal models. In the present study, the tail suspension test (TST) and forced swim test (FST) were used to examine the roles of MOP and DOP in behavioral despair. MOP-KO mice and WT mice were treated with KNT-127 (10 mg/kg), a selective DOP agonist. The results indicated a significant decrease in immobility time in the KNT-127 group compared with the saline group in all genotypes in both tests. In the saline groups, immobility time significantly decreased in MOP-KO mice compared with WT mice in both tests. In female MOP-KO mice, KNT-127 significantly decreased immobility time in the TST compared with WT mice. In male MOP-KO mice, however, no genotypic differences were found in the TST after either KNT-127 or saline treatment. Thus, at least in the FST and TST, the activation of DOP and absence of MOP had additive effects in reducing measures of behavioral despair, suggesting that effects on this behavior by DOP activation occur independently of MOP.
キーワード
Antidepressant
μ-opioid receptor
δ-opioid receptor agonist
Anxiolytic
Lack of motivated behavior
カテゴリ
医学研究科
学術雑誌論文
権利
© 2022 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
詳細を表示
資源タイプ
journal article
言語
English (英語)
ISSN
1347-8613
OPACで所蔵を検索
CiNiiで学外所蔵を検索
eISSN
1347-8648
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.1016/j.jphs.2022.12.008
ホームへ戻る