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https://hdl.handle.net/20.500.14094/0100488547
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2024-06-12
21:33 集計
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0100488547 (fulltext)
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0100488547
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open access
出版タイプ
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タイトル
ESCRT-III-dependent and -independent egress of herpesviruses
著者
著者ID
A2591
研究者ID
1000030704928
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail.html?systemId=1f0aa402893ddbca520e17560c007669
著者名
Arii, Jun
有井, 潤
アリイ, ジュン
所属機関名
医学研究科
収録物名
Frontiers in Virology
巻(号)
4
ページ
1378054
出版者
Frontiers Media
刊行日
2024-03-05
公開日
2024-04-08
抄録
Enveloped viruses complete their replication cycle by forming virions that bud from infected cells through membrane scission. The mechanisms by which this is achieved are less well-understood than the well-characterized membrane scission of vesicles budding inwards into the cytosol. The scission of vesicles that bud away from the cytosol is mediated by machinery of the endosomal sorting complexes required for transport (ESCRT)-III, which is highjacked by viruses of several different families. Other groups of viruses can bud independently of ESCRT-III activity. It has not been fully elucidated how the latter achieve this in the absence of host ESCRT-III, but it is known that some viral proteins directly mediate membrane scission. The Herpesviridae constitute a family of highly diverse viruses that bud at the inner nuclear membrane and cytoplasmic membranes in infected cells. Many investigators have attempted to determine the mechanism of membrane scission during herpesvirus budding, and have found this to be complex, not exactly conforming to either of the two methods. The present review attempts to synthesize the disparate findings into a model of herpesvirus egress based on both ESCRT-mediated and viral protein-mediated mechanisms.
キーワード
viral egress
budding
ESCRT
herpesvirus
membrane scission
カテゴリ
医学研究科
学術雑誌論文
権利
© 2024 Arii.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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資源タイプ
journal article
言語
English (英語)
eISSN
2673-818X
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関連情報
DOI
https://doi.org/10.3389/fviro.2024.1378054
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