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https://doi.org/10.24546/81005032
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2024-05-14
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81005032 (fulltext)
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81005032
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open access
出版タイプ
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タイトル
Subcortically and Callosally Projecting Neurons are Distinct Neuronal Pools in the Motor Cortex of the Reeler Mouse
著者
Imai, Hideaki ; Yamamoto, Tatsuro ; Katsuyama, Yu ; Kikkawa, Satoshi ; Terashima, Toshio
著者名
Imai, Hideaki
著者名
Yamamoto, Tatsuro
著者名
Katsuyama, Yu
著者名
Kikkawa, Satoshi
著者名
Terashima, Toshio
収録物名
The Kobe journal of the medical sciences
巻(号)
58(3)
ページ
86-95
出版者
神戸大学医学部
Kobe University School of Medicine
刊行日
2012
公開日
2013-06-03
抄録
Subcortically projecting neurons and callosally projecting ones are distinct neuronal pools in the cerebral cortex of the rodents. However, cortical efferent neurons are known to project multiple targets transiently by plural collateral axons. These plural axons are eliminated during prenatal and postnatal development. In the cerebral cortex of the Reelin-deficient mouse, reeler, which is caused by mutation of the reelin gene, cortical efferent neurons are ectopically distributed. However, it is still unknown whether cortical efferent neurons in the reeler mouse lose surplus collateral axons or maintain them during developmental periods. If surplus collaterals of malpositioned cortical neurons are not eliminated, neurons projecting subcortically may project their axons to the contralateral hemisphere. To test this plausible hypothesis, we made double injections of two fluorescent dyes, Fast Blue and Diamidino yellow dihydrochloride into two of three regions, i.e., upper cervical cord, ventral lateral thalamic nucleus, and contralateral motor cortex of the normal and reeler mice, to label corticospinal, corticothalamic and callosal commissure neurons in the motor cortex, retrogradely. No double labeled neurons were identified in the motor cortex of the normal and reeler mice, although the distribution patterns of these cortical efferent neurons were completely different between normal and reeler mice. These findings strongly suggest that collateral elimination of cortical efferent neurons during developing periods are not affected in this mutant mouse.
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The Kobe journal of the medical sciences
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58巻
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58巻3号(2012)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
0023-2513
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NCID
AA00711740
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http://www.med.kobe-u.ac.jp/journal/contents.html
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