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https://hdl.handle.net/20.500.14094/90005935
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2024-04-25
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90005935 (fulltext)
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メタデータID
90005935
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open access
出版タイプ
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タイトル
Detoxification of Reactive Carbonyl Species by Glutathione Transferase Tau Isozymes
著者
Mano, Jun'ichi ; Kanameda, Sayaka ; Kuramitsu, Rika ; Matsuura, Nagisa ; Yamauchi, Yasuo
著者名
Mano, Jun'ichi
著者名
Kanameda, Sayaka
著者名
Kuramitsu, Rika
著者名
Matsuura, Nagisa
著者ID
A1632
研究者ID
1000090283978
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3ace5acfb9e5a0a3520e17560c007669
著者名
Yamauchi, Yasuo
山内, 靖雄
ヤマウチ, ヤスオ
所属機関名
農学研究科
収録物名
Frontiers in Plant Science
巻(号)
10
ページ
487-487
出版者
Frontiers Media
刊行日
2019-04-24
公開日
2019-05-09
抄録
Oxidative stimuli to living cells results in the formation of lipid peroxides, from which various aldehydes and ketones (oxylipin carbonyls) are inevitably produced. Among the oxylipin carbonyls, those with an α,β-unsaturated bond are designated as reactive carbonyl species (RCS) because they have high electrophilicity and biological activity. Plants have arrays of dehydrogenases and reductases to metabolize a variety of RCS that occur in the cells, but these enzymes are not efficient to scavenge the most toxic RCS (i.e., acrolein) because they have only low affinity. Two glutathione transferase (GST) isozymes belonging to the plant-specific Tau class were recently observed to scavenge acrolein with KM values at a submillimolar level. This suggests that GST could also be involved in the defense system against RCS. We tested the activities of 23 Tau isozymes of Arabidopsis thaliana for five types of RCS, and the results revealed that 11 isozymes recognized either acrolein or 4-hydroxy-(E)-2-nonenal or both as a substrate(s). Such RCS-scavenging activities indicate the potential contribution of GST to RCS scavenging in plants, and they may account for the stress tolerance conferred by several Tau isozymes. RCS are therefore a strong candidate for endogenous substrates of plant GSTs.
キーワード
acrolein
lipid peroxide
oxidative stress
oxylipin
reactive electrophile species
redox signal
カテゴリ
農学研究科
学術雑誌論文
権利
© 2019 Mano, Kanameda, Kuramitsu, Matsuura and Yamauchi.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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資源タイプ
journal article
言語
English (英語)
eISSN
1664-462X
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関連情報
DOI
https://doi.org/10.3389/fpls.2019.00487
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