神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90006132
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2024-06-05
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90006132 (fulltext)
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メタデータID
90006132
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open access
出版タイプ
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タイトル
Idiopathic multicentric Castleman’s disease: a clinicopathologic study in comparison with IgG4-related disease
著者
Otani, Kyoko ; Inoue, Dai ; Fujikura, Kohei ; Komori, Takahiro ; Abe-Suzuki, Shiho ; Tajiri, Takuma ; Itoh, Tomoo ; Zen, Yoh
著者名
Otani, Kyoko
著者名
Inoue, Dai
著者名
Fujikura, Kohei
著者名
Komori, Takahiro
著者ID
A1959
研究者ID
1000030632111
著者名
Abe-Suzuki, Shiho
阿部, 志保
アベ, シホ
所属機関名
医学部附属病院
著者名
Tajiri, Takuma
著者名
Itoh, Tomoo
著者ID
A0341
研究者ID
1000090377416
著者名
Zen, Yoh
全, 陽
ゼン, ヨウ
所属機関名
医学研究科
収録物名
Oncotarget
巻(号)
9(6)
ページ
6691-6706
出版者
Impact Journals
刊行日
2018-01-09
公開日
2019-07-01
抄録
The present study aimed to compare clinicopathologic features between idiopathic multicentric Castleman’s disease (n=22) and IgG4-related disease (n=26). Histology was analyzed using lymph node and lung biopsies. The expression of IL-6 mRNA in tissue was also examined by in situ hybridization and real-time PCR. Patients with idiopathic multicentric Castleman’s disease were significantly younger than those with IgG4-related disease (p<0.001). Splenomegaly was observed in only idiopathic multicentric Castleman’s disease (p=0.002), while pancreatitis and sialo-dacryoadenitis were restricted to IgG4-related disease (both p<0.001). Serum IgG4 concentrations were commonly elevated at >135 mg/dL in both groups (p=0.270). However, the IgG4/IgG ratio in IgG4-related disease was significantly higher than that in Castleman’s disease (p<0.001). Histologically, sheet-like plasmacytosis was highly characteristic of idiopathic multicentric Castleman’s disease (p<0.001), while plasmacytic infiltration in IgG4-related disease was always associated with intervening lymphocytes. Similar to laboratory findings, the IgG4/IgG-positive plasma cell ratio, but not the IgG4-positive cell count, was significantly higher in IgG4-related disease (p=0.002). Amyloid-like hyalinized fibrosis was found in 6/8 lung biopsies (75%) of Castleman’s disease. The over-expression of IL-6 mRNA was not confirmed in tissue samples of Castleman’s disease by either in situ hybridization or quantitative real-time PCR. In conclusion, useful data for a differential diagnosis appear to be age, affected organs, the serum IgG4/IgG ratio, sheet-like plasmacytosis in biopsies, and the IgG4/IgG-positive cell ratio on immunostaining. Since IL-6 was not over-expressed in tissue of idiopathic multicentric Castleman’s disease, IL-6 may be produced outside the affected organs, and circulating IL-6 may lead to lymphoplasmacytosis at nodal and extranodal sites.
キーワード
Castleman
IL-6
IgG4
autoimmune pancreatitis
pathology
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License. (https://creativecommons.org/licenses/by/3.0/)
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資源タイプ
journal article
言語
English (英語)
eISSN
1949-2553
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関連情報
DOI
https://doi.org/10.18632/oncotarget.24068
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