神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90008615
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2024-06-09
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90008615 (fulltext)
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メタデータID
90008615
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Oral chronic sulforaphane effects on heavy resistance exercise: Implications for inflammatory and muscle damage parameters in young practitioners
著者
Sato, Koji ; Kihara, Hinata ; Kumazawa, Yoka ; Tatara, Koki
著者ID
A0584
研究者ID
1000020584022
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b09e77be63b04dce520e17560c007669
著者名
Sato, Koji
佐藤, 幸治
サトウ, コウジ
所属機関名
人間発達環境学研究科
著者名
Kihara, Hinata
著者名
Kumazawa, Yoka
著者名
Tatara, Koki
収録物名
Nutrition
巻(号)
90
ページ
111266
出版者
Elsevier
刊行日
2021-10
公開日
2022-11-01
抄録
Objective: Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulforaphane ingestion suppresses heavy resistance exercise-induced muscle damage parameters in humans remains unknown. Therefore, this study investigated the effects of oral chronic sulforaphane ingestion on heavy resistance exercise-induced muscle damage parameters. Methods: The study had a randomized, double-blind, placebo-controlled, cross-over design. Ten healthy young men (age: 22.0 ± 0.3 y; body weight: 62.6 ± 2.4 kg; height: 171.0 ± 0.1 cm) were administered placebo or sulforaphane (30 mg/d) for 4 wk at the first trial, then after a 4-wk washout period, the participants were administered the opposite treatment for 4 wk at the second trial. The participants were subjected to heavy resistance exercise (bench press, 85% of one-repetition maximum for three times with eight repetitions) after each administration, and blood samples were collected before and at 30 min and 24 h after each exercise session. Results: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane. Conclusions: Together, these findings suggest that the oral chronic intake of sulforaphane suppressed the heavy resistance exercise-induced increase in muscle damage parameter and expression of inflammatory cytokines. The chronic use of sulforaphane may be a novel therapeutic candidate for the prevention of muscle damage in athletes training daily with high-intensity exercise.
キーワード
Creatine kinase
Supplementation
Exercise
Cytokine
Tissue damage
カテゴリ
人間発達環境学研究科
学術雑誌論文
権利
© 2021 Elsevier Inc.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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資源タイプ
journal article
言語
English (英語)
ISSN
0899-9007
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NCID
AA10745727
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関連情報
DOI
https://doi.org/10.1016/j.nut.2021.111266
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