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https://hdl.handle.net/20.500.14094/90009311
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2024-05-22
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90009311 (fulltext)
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90009311
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open access
出版タイプ
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タイトル
Quercetin treatment protects the Achilles tendons of rats from oxidative stress induced by hyperglycemia
著者
Yoshikawa, Tomoya ; Mifune, Yutaka ; Inui, Atsuyuki ; Nishimoto, Hanako ; Yamaura, Kohei ; Mukohara, Shintaro ; Shinohara, Issei ; Kuroda, Ryosuke
著者名
Yoshikawa, Tomoya
著者ID
A0826
研究者ID
1000080608464
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a355369a8c047f2e520e17560c007669
著者名
Mifune, Yutaka
美舩, 泰
ミフネ, ユタカ
所属機関名
医学部附属病院
著者ID
A2076
研究者ID
1000070457092
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cf677d34bcd544b8520e17560c007669
著者名
Inui, Atsuyuki
乾, 淳幸
イヌイ, アツユキ
所属機関名
医学部附属病院
著者ID
A2834
研究者ID
1000030707154
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=6179d01ac8add41b520e17560c007669
著者名
Nishimoto, Hanako
西本, 華子
ニシモト, ハナコ
所属機関名
医学部附属病院
著者名
Yamaura, Kohei
著者名
Mukohara, Shintaro
著者名
Shinohara, Issei
著者ID
A0783
研究者ID
1000080379362
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f51cbfc82378ae63520e17560c007669
著者名
Kuroda, Ryosuke
黒田, 良祐
クロダ, リョウスケ
所属機関名
医学研究科
収録物名
BMC Musculoskeletal Disorders
巻(号)
23(1)
ページ
563
出版者
BMC
刊行日
2022-06-10
公開日
2022-06-21
抄録
Background Quercetin, a flavonoid abundantly in vegetables and fruits, exerts antioxidant and anti-inflammatory effects. We investigated the protective effects of quercetin against oxidative stress in the Achilles tendons of diabetic rats. Methods Cells were collected from the Achilles tendons of Sprague-Dawley rats and cultured under four conditions: regular glucose (RG) without quercetin (Quer-), RG with quercetin (Quer +), high-glucose (HG) Quer-, and HG Quer + . The expression of genes related to NADPH oxidase (NOX) and inflammation, reactive oxygen species accumulation, and apoptosis rates was analyzed. Additionally, diabetic rats were divided into two groups and subjected to quercetin (group Q) or no quercetin (group C) treatment. Histological evaluation and expression analysis of relevant genes in the Achilles tendon were performed. Results In rat tendon-derived cells, the expression of Nox1, Nox4, and Il6; reactive oxygen species accumulation; and apoptosis rates were significantly decreased by quercetin treatment in the HG group. The collagen fiber arrangement was significantly disorganized in the diabetic rat Achilles tendons in group C compared with that in group Q. The mRNA and protein expression levels of NOX1 and NOX4 were significantly decreased upon quercetin treatment. Furthermore, the expression of Il6, type III collagen, Mmp2, and Timp2 was significantly decreased, whereas that of type I collagen was significantly increased in group Q compared with that in group C. Conclusions Quercetin treatment decreases NOX expression and thus exerts antioxidant and anti-inflammatory effects in the Achilles tendons of diabetic rats. Quercetin treatment may be effective against diabetic tendinopathy.
キーワード
Quercetin
Oxidative stress
Antioxidant effect
Diabetic tendinopathy
Rat diabetic model
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
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© The Author(s) 2022.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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資源タイプ
journal article
言語
English (英語)
eISSN
1471-2474
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NCID
AA12035278
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DOI
https://doi.org/10.1186/s12891-022-05513-4
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