In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s 
Disease at Ultra-High Magnetic Field compared to Histology

Tuzzi, E; Hagberg, G; Balla, D; Loureiro, J; Neumann, M; Laske, C; Pohmann, R; Valverde, M

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In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s Disease at Ultra-High Magnetic Field compared to Histology

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Tuzzi, E
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hagberg, G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Balla, D
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Loureiro, J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann, R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society;

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Valverde, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Tuzzi, E., Hagberg, G., Balla, D., Loureiro, J., Neumann, M., Laske, C., et al. (2017). In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s Disease at Ultra-High Magnetic Field compared to Histology. In 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017) (pp. 677-678).

Cite as: https://hdl.handle.net/21.11116/0000-0000-C5A2-A

Abstract

Amyloid-β plaques are classical hallmarks of the post-mortem Alzheimer’s Disease (AD) brain. Ultra-High-Field (UHF) MRI provides a compelling means to investigate pathological processes at an unprecedented level of detail. ß-amyloid plaques can be detected in T2* weighted images at UHF, ex-vivo, due to the local iron content and to the plaque geometry per sè. With this study we aim to explore the source of the observed MR signal changes in AD at UHF using quantitative MRI methods in-vivo and ex-vivo.