Does RF spoiling enhance human in-vivo brain MR Current Density Imaging (MRCDI)?

Göksu, C; Hanson, LG; Siebner, H; Ehses, P; Scheffler, K; Thielscher, A

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Does RF spoiling enhance human in-vivo brain MR Current Density Imaging (MRCDI)?

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Ehses, P
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/5048.html
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Citation

Göksu, C., Hanson, L., Siebner, H., Ehses, P., Scheffler, K., & Thielscher, A. (2019). Does RF spoiling enhance human in-vivo brain MR Current Density Imaging (MRCDI)?. Poster presented at 27th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2019), Montréal, QC, Canada.

Cite as: https://hdl.handle.net/21.11116/0000-0003-96D9-F

Abstract

MRCDI is an emerging modality for non-invasive measurement of weak currents in the human brain, which is important in several neuroscientific applications. It is based on current-induced field measurements and requires high sensitivity to the extrinsic field changes. Measurement sensitivity can be compromised by irrelevant field changes caused by physiological variation. Here, we compare the performance of the so far most sensitive MRCDI method based on steady-state free precession free induction decay (SSFP-FID) with its RF-spoiled counterpart fast low angle shot (FLASH). No significant sensitivity differences were observed in slices covering the upper part of the brain, but SSFP-FID had ~20% lower noise floors in lower slices. For the relevant acquisition parameters, FLASH exhibits no remarkable image quality enhancements in 2D.