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Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools

MPS-Authors
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Seeberger,  Peter H.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121626

Martin,  Christopher E.
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121178

Bröcker,  Felix
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121100

Chakkumkal,  Anish
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Seeberger, P. H., Martin, C. E., Bröcker, F., & Chakkumkal, A.(2013). Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-1401-0
Abstract
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile
glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1---+3 ) -B-D-Glcp- ( 1---+4) - [a-L-Rhap- ( 1---+3 ] -aD-
Glcp- ( 1---+2 ) -a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at
least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous
methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof,
in particular as vaccines and diagnostic tools.