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Journal Article

Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification

MPS-Authors
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Gambino,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gambino,  T
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://pubs.rsc.org/en/content/articlepdf/2020/cc/d0cc04416d
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Citation

Gambino, G., Gambino, T., & Angelovski, G. (2020). Combination of bioresponsive chelates and perfluorinated lipid nanoparticles enables in vivo MRI probe quantification. Chemical Communications, 56(66), 9433-9436. doi:10.1039/d0cc04416d.


Cite as: https://hdl.handle.net/21.11116/0000-0006-D1B4-2
Abstract
We developed a nanosized perfluorocarbon-based system with incorporated paramagnetic Gd(iii) chelates, able to generate a quantitative 19F MRI signal, while in parallel capable of modulating the 1H MRI signal in response to the coordination of Ca2+ ions. Subsequently, we performed experiments in vivo and estimated the concentration of the applied probe in the tissue by means of 19F MRI.