Serial synchrotron crystallography for time-resolved structural biology

Pearson, A. R.; Mehrabi, P.

doi:10.1016/j.sbi.2020.06.019

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Serial synchrotron crystallography for time-resolved structural biology

MPG-Autoren

/persons/resource/persons209117

Mehrabi, P.
Miller Group, Atomically Resolved Dynamics Department, Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society;

Externe Ressourcen

https://dx.doi.org/10.1016/j.sbi.2020.06.019
(Verlagsversion)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

1-s2.0-S0959440X20301184-main.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Pearson, A. R., & Mehrabi, P. (2020). Serial synchrotron crystallography for time-resolved structural biology. Current Opinion in Structural Biology, 65, 168-174. doi:10.1016/j.sbi.2020.06.019.

Zitierlink: https://hdl.handle.net/21.11116/0000-0007-37A8-E

Zusammenfassung

The current state-of-the-art experiments in time-resolved structural biology are undoubtedly the recent extremely impressive results that are emerging from XFEL-based experiments. However, there is a large range of macromolecular systems where the biological interest is predominantly in the slower dynamics (μs–s), that produce well diffracting microcrystals, and for which synchrotron-based experiments are extremely well suited. The combination of microfocus X-ray beams and the development of a range of sample delivery platforms has now made routine millisecond time-resolved experiments at microfocus macromolecular crystallography beamlines a real possibility and is driving development of dedicated endstations for time-resolved serial synchrotron crystallography.