Metabolic Instruction of Immunity

Buck, Michael; Sowell, Ryan T.; Kaech, Susan M.; Pearce, Erika L.

doi:10.1016/j.cell.2017.04.004

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Metabolic Instruction of Immunity

MPG-Autoren

Buck, Michael
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons201431

Pearce, Erika L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Externe Ressourcen

https://www.sciencedirect.com/science/article/pii/S0092867417304166?via%3Dihub
(Verlagsversion)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Buck, M., Sowell, R. T., Kaech, S. M., & Pearce, E. L. (2017). Metabolic Instruction of Immunity. Cell, 169, 570-586. doi:10.1016/j.cell.2017.04.004.

Zitierlink: https://hdl.handle.net/21.11116/0000-0000-BF8E-A

Zusammenfassung

Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.