Childhood exposure to hunger: associations with health outcomes in later life 
and epigenetic markers

Perna, Laura; Zhang, Yan; Wild, Beate; Kliegel, Matthias; Ihle, Andreas; Schoettker, Ben; Mons, Ute; Brenner, Hermann

doi:10.2217/epi-2019-0333

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers

MPS-Authors

/persons/resource/persons262078

Perna, Laura
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Perna, L., Zhang, Y., Wild, B., Kliegel, M., Ihle, A., Schoettker, B., Mons, U., & Brenner, H. (2020). Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers. EPIGENOMICS, 12(21), 1861-1870. doi:10.2217/epi-2019-0333.

引用: https://hdl.handle.net/21.11116/0000-0008-2766-A

要旨

Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association.