Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by 
solid-phase microextraction

Spiteller, D.; Spiteller, G.

doi:10.1002/(SICI)1521-3773(20000204)39:3<583::AID-ANIE583>3.0.CO;2-O

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Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction

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Spiteller, D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Spiteller, D., & Spiteller, G. (2000). Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction. Angewandte Chemie International Edition, 39(3), 583-585. doi:10.1002/(SICI)1521-3773(20000204)39:3<583:AID-ANIE583>3.0.CO;2-O.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A395-C

Abstract

The oxidation of low‐density lipoprotein (LDL) in vitro was studied by a combination of solid‐phase microextraction and GC/MS. 2‐trans,4‐cis‐2,4‐Decadienal, which is strongly toxic in vitro, was detected as the early oxidation product. This compound is degraded further to hexanal and (by cyclization of 4‐hydroxy‐2‐nonenal) to 2‐pentylfuran.