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Journal Article

Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1

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Zhao,  Lei
Chemical Genomics Center of the MPS, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Zhao, L., Awori, R. M., Kaiser, M., Gross, J., Opatz, T., & Bode, H. B. (2019). Structure, Biosynthesis, and Bioactivity of Photoditritide from Photorhabdus temperata Meg1. JOURNAL OF NATURAL PRODUCTS, 82(12), 3499-3503. doi:10.1021/acs.jnatprod.9b00932.


Cite as: https://hdl.handle.net/21.11116/0000-000A-05A0-B
Abstract
A new cyclic peptide photoditritide (1), containing two rare amino acid D-homoarginine residues, was isolated from Photorhabdus temperata Meg1 after the nonribosomal peptide synthetase encoding gene pdtS was activated via promoter exchange. The structure of 1 was elucidated by HR-MS and NMR experiments. The absolute configurations of amino acids were determined according to the advanced Marfey's method after hydrolysis of 1. Bioactivity testing of 1 revealed potent antimicrobial activity against Micrococcus luteus with an MIC value of 3.0 mu M and weak antiprotozoal activity against Trypanosoma brucei rhodesiense with an IC50 value of 13 mu M. Additionally, the biosynthetic pathway of 1 was also proposed.