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Resolve fiber crossings and substructures using orientation distribution function (ODF) of decomposed sub-voxel paramagnetic and diamagnetic susceptibility

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Gkotsoulias,  Dimitrios
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Chen, J., Gkotsoulias, D., Jäffe, J., Crockford, C., Wittig, R., Möller, H. E., et al. (2022). Resolve fiber crossings and substructures using orientation distribution function (ODF) of decomposed sub-voxel paramagnetic and diamagnetic susceptibility. Poster presented at 2022 Joint Annual Meeting ISMRM-ESMRMB, London, United Kingdom.


Cite as: https://hdl.handle.net/21.11116/0000-000B-06F5-A
Abstract
DECOMPOSE-QSM was applied on high angular-resolution multi-echo gradient-echo data of a chimpanzee brain to evaluate its ability in resolving orientation mixture of substructure fiber bundles. The orientation distribution function (ODF) of the separated paramagnetic and diamagnetic susceptibility provides smooth transitions of multiple fiber orientations. Additionally, the paramagnetic maps from DECOMPOSE show a potential to resolve fiber crossings in deep gray matter regions.