Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  DetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Converging patterns of aging-associated brain volume loss and tissue microstructure differences

MPG-Autoren
/persons/resource/persons20042

Taubert,  Marco
Faculty of Humanities, Social Science & Education, Otto von Guericke University Magdeburg, Germany;
Center for Behavioral Brain Sciences, Magdeburg, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19617

Draganski,  Bogdan
Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Taubert, M., Roggenhofer, E., Melie-Garcia, L., Muller, S., Lehmann, N., Preisig, M., et al. (2020). Converging patterns of aging-associated brain volume loss and tissue microstructure differences. Neurobiology of Aging, 88, 108-118. doi:10.1016/j.neurobiolaging.2020.01.006.


Zitierlink: https://hdl.handle.net/21.11116/0000-0005-7E21-9
Zusammenfassung
Given the worldwide increasing socio-economic burden of ageing-associated brain diseases, there is pressing need to gain in-depth knowledge about the neuro-biology of brain anatomy changes across the lifespan. Advances in quantitative magnetic resonance imaging (MRI) sensitive to brain’s myelin, iron and free water content allow for a detailed in vivo investigation of ageing-related changes whilst reducing spurious morphometry differences. Main aim of our study is to link previous morphometry findings in ageing to microstructural tissue properties in a large-scale cohort (n=966, age range 46-86y). Addressing previous controversies in the field, we present results obtained with different approaches to adjust local findings for global effects. Beyond the confirmation of age-related atrophy, myelin and free water decreases, we report proportionally steeper volume, iron and myelin decline in sensorimotor and subcortical areas paralleled by free water increase. We demonstrate ageing-related white matter volume, myelin and iron loss in fronto-striatal projections. Our findings provide robust evidence for spatial overlap between volume and tissue property differences in ageing that affect predominantly motor and executive networks.