Identification of plant microRNA homologs

Dezulian, T; Remmert, M; Palatnik, JF; Weigel, D; Huson, DH

doi:10.1093/bioinformatics/bti802

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Identification of plant microRNA homologs

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Palatnik, JF
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Weigel, D
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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引用

Dezulian, T., Remmert, M., Palatnik, J., Weigel, D., & Huson, D. (2006). Identification of plant microRNA homologs. Bioinformatics, 22(3), 359-360. doi:10.1093/bioinformatics/bti802.

引用: https://hdl.handle.net/21.11116/0000-000B-4509-E

要旨

MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs that regulate gene and protein expression in plants and animals. MiRNAs have so far been identified mostly by specific cloning of small RNA molecules, complemented by computational methods. We present a computational identification approach that is able to identify candidate miRNA homologs in any set of sequences, given a query miRNA. The approach is based on a sequence similarity search step followed by a set of structural filters.