The dissociation of nuclear and centrosomal division in gnu, a mutation causing 
giant nuclei in Drosophila

Freeman, M; Nüsslein-Volhard, C; Glover, DM

doi:10.1016/0092-8674(86)90666-5

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila

MPS-Authors

/persons/resource/persons271460

Nüsslein-Volhard, C
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Freeman, M., Nüsslein-Volhard, C., & Glover, D. (1986). The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila. Cell, 46(3), 457-468. doi:10.1016/0092-8674(86)90666-5.

Cite as: https://hdl.handle.net/21.11116/0000-000B-6A78-8

Abstract

We describe a recessive, maternal-effect lethal mutation of Drosophila, gnu. gnu uncouples nuclear division from many cytoplasmic events of mitosis in the Drosophila embryo. Embryos from homozygous females are defective in nuclear division, but not in DNA replication, and therefore develop a small number of giant nuclei. Centrosomes divide independently of nuclear division and migrate to the surface of the syncytial blastoderm. There they nucleate microtubules into asters, which appear normal at first but become very large. Only later, when the giant nuclei begin to break down, are spindles sometimes formed. The cortical actin of these embryos develops into a characteristic network.