Regulation of extracellular cyclic-AMP-phosphodiesterase activity during 
development of Dictyostelium discoideum

Riedel, V; Gerisch, G

doi:10.1016/0006-291x(71)90370-6

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Regulation of extracellular cyclic-AMP-phosphodiesterase activity during development of Dictyostelium discoideum

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Riedel, V
Gerisch Group, Friedrich Miescher Laboratory, Max Planck Society;

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Gerisch, G
Gerisch Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Riedel, V., & Gerisch, G. (1971). Regulation of extracellular cyclic-AMP-phosphodiesterase activity during development of Dictyostelium discoideum. Biochemical and Biophysical Research Communications, 42(1), 119-124. doi:10.1016/0006-291x(71)90370-6.

Cite as: https://hdl.handle.net/21.11116/0000-000C-6DCA-7

Abstract

The cAMP-PDE∗ released into the medium of cultures during growth is inhibited by a factor which is produced early in the phase of transition from growth to cell aggregation. In a non-aggregating mutant, active PDE is over-produced and not depressed in this developmental stage, although the enzyme is sensitive to wild-type inhibitor. In two other mutants, only low PDE activities were measured throughout the growth and transition phases. The cAMP-PDE inhibition may trigger development by rising the external cAMP level.