Spontaneous variability in gamma dynamics described by a damped harmonic 
oscillator driven by noise

Spyropoulos, Georgios; Saponati, Matteo; Dowdall, Jarrod Robert; Schölvinck, Marieke; Bosman, Conrado Arturo; Lima, Bruss; Peter, Alina; Onorato, Irene; Klon-Lipok, Johanna; Roese, Rasmus; Neuenschwander, Sergio; Fries, Pascal; Vinck, Martin

doi:10.1038/s41467-022-29674-x

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学術論文

Spontaneous variability in gamma dynamics described by a damped harmonic oscillator driven by noise

MPS-Authors

Spyropoulos, Georgios
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Saponati, Matteo
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Dowdall, Jarrod Robert
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

/persons/resource/persons141637

Schölvinck, Marieke
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Havenith & Schölvinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Peter, Alina
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Onorato, Irene
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Klon-Lipok, Johanna
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Roese, Rasmus
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

/persons/resource/persons141609

Fries, Pascal
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Fries Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

/persons/resource/persons274130

Vinck, Martin
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

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https://www.nature.com/articles/s41467-022-29674-x
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Spyropoulos_2022_SpontaneousVariability.pdf
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引用

Spyropoulos, G., Saponati, M., Dowdall, J. R., Schölvinck, M., Bosman, C. A., Lima, B., Peter, A., Onorato, I., Klon-Lipok, J., Roese, R., Neuenschwander, S., Fries, P., & Vinck, M. (2022). Spontaneous variability in gamma dynamics described by a damped harmonic oscillator driven by noise. Nature Communications, 13:. doi:10.1038/s41467-022-29674-x.

引用: https://hdl.handle.net/21.11116/0000-000C-85D1-1

要旨

Circuits of excitatory and inhibitory neurons generate gamma-rhythmic activity (30–80 Hz). Gamma-cycles show spontaneous variability in amplitude and duration. To investigate the mechanisms underlying this variability, we recorded local-field-potentials (LFPs) and spikes from awake macaque V1. We developed a noise-robust method to detect gamma-cycle amplitudes and durations, which showed a weak but positive correlation. This correlation, and the joint amplitude-duration distribution, is well reproduced by a noise-driven damped harmonic oscillator. This model accurately fits LFP power-spectra, is equivalent to a linear, noise-driven E-I circuit, and recapitulates two additional features of gamma: (1) Amplitude-duration correlations decrease with oscillation strength; (2) amplitudes and durations exhibit strong and weak autocorrelations, respectively, depending on oscillation strength. Finally, longer gamma-cycles are associated with stronger spike-synchrony, but lower spike-rates in both (putative) excitatory and inhibitory neurons. In sum, V1 gamma-dynamics are well described by the simplest possible model of gamma: A damped harmonic oscillator driven by noise.