A butterfly effect: From a single nucleotide to altered immunity

Bechtella, Leïla; Pagel, Kevin

doi:10.1016/j.chempr.2023.02.014

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A butterfly effect: From a single nucleotide to altered immunity

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Pagel, Kevin
Molecular Physics, Fritz Haber Institute, Max Planck Society;

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Citation

Bechtella, L., & Pagel, K. (2023). A butterfly effect: From a single nucleotide to altered immunity. Chem, 9(3), 554-556. doi:10.1016/j.chempr.2023.02.014.

Cite as: https://hdl.handle.net/21.11116/0000-000C-F44E-A

Abstract

Proteoforms show subtle differences that are difficult to detect. Generated by single-nucleotide polymorphism or post-translational modifications, they are challenging to analyze and difficult to design for therapeutic applications. In this issue of Chem, Robinson and co-workers present a systematic native mass spectrometry (MS) study in which the fine modulations of SERPIN proteoforms are linked to their activity.