Electrical field based dosing improves non-invasive brain stimulation

Numssen, Ole; Kuhnke, Philipp; Weise, Konstantin; Hartwigsen, Gesa

doi:10.1101/2023.07.31.551253

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

Preprint

Electrical field based dosing improves non-invasive brain stimulation

MPS-Authors

/persons/resource/persons209297

Numssen, Ole
Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons224446

Kuhnke, Philipp
Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons212471

Weise, Konstantin
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons185449

Hartwigsen, Gesa
Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

Numssen_Kuhnke_pre.pdf
(プレプリント), 5MB

付随資料 (公開)

There is no public supplementary material available

引用

Numssen, O., Kuhnke, P., Weise, K., & Hartwigsen, G. (2023). Electrical field based dosing improves non-invasive brain stimulation. bioRxiv. doi:10.1101/2023.07.31.551253.

引用: https://hdl.handle.net/21.11116/0000-000D-9E9F-F

要旨

Non-invasive brain stimulation (NIBS) methods, such as transcranial magnetic stimulation (TMS), are invaluable tools to modulate cortical activity and behavior, but high within- and between-subject variability limit their efficacy and reliability. Here, we explore the potential of electrical field (e-field) based NIBS dosing to reduce its variability and discuss current challenges as well as future pathways. In contrast to previous dosing approaches, e-field dosing optimally matches the stimulation strength across cortical areas, both within and across individuals. Challenges include methodological uncertainties of the e-field calculation, target definitions, and comparability of different stimulation thresholds across cortical areas and NIBS protocols. Despite these challenges, e-field dosing promises to substantially improve NIBS applications in neuroscientific research and personalized medicine.