Drosophila MIC10b can polymerize into cristae-shaping filaments

Stephan, Till; Stoldt, Stefan; Barbot, Mariam; Carney, Travis D; Lange, Felix; Bates, Mark; Bou Dib, Peter; Inamdar, Kaushik; Shcherbata, Halyna R; Meinecke, Michael; Riedel, Dietmar; Dennerlein, Sven; Rehling, Peter; Jakobs, Stefan

doi:10.26508/lsa.202302177

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学術論文

Drosophila MIC10b can polymerize into cristae-shaping filaments

MPS-Authors

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Stephan, Till
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Stoldt, Stefan
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Barbot, Mariam
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Lange, Felix
Research Group of Mitochondrial Structure and Dynamics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Bates, Mark
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

/persons/resource/persons297108

Bou Dib, Peter
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Inamdar, Kaushik
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

/persons/resource/persons15710

Riedel, Dietmar
Facility for Transmission Electron Microscopy Fassberg Campus, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Rehling, Peter
MPI-NAT Fellow Mitochondrial Biogenesis and Assembly of membrane Protein Complexes, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Jakobs, Stefan
Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;
Research Group of Mitochondrial Structure and Dynamics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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引用

Stephan, T., Stoldt, S., Barbot, M., Carney, T. D., Lange, F., Bates, M., Bou Dib, P., Inamdar, K., Shcherbata, H. R., Meinecke, M., Riedel, D., Dennerlein, S., Rehling, P., & Jakobs, S. (2024). Drosophila MIC10b can polymerize into cristae-shaping filaments. Life science alliance, 7(4):. doi:10.26508/lsa.202302177.

引用: https://hdl.handle.net/21.11116/0000-000F-0EB4-7

要旨

Cristae are invaginations of the mitochondrial inner membrane that are crucial for cellular energy metabolism. The formation of cristae requires the presence of a protein complex known as MICOS, which is conserved across eukaryotic species. One of the subunits of this complex, MIC10, is a transmembrane protein that supports cristae formation by oligomerization. In Drosophila melanogaster, three MIC10-like proteins with different tissue-specific expression patterns exist. We demonstrate that CG41128/MINOS1b/DmMIC10b is the major MIC10 orthologue in flies. Its loss destabilizes MICOS, disturbs cristae architecture, and reduces the life span and fertility of flies. We show that DmMIC10b has a unique ability to polymerize into bundles of filaments, which can remodel mitochondrial crista membranes. The formation of these filaments relies on conserved glycine and cysteine residues, and can be suppressed by the co-expression of other Drosophila MICOS proteins. These findings provide new insights into the regulation of MICOS in flies, and suggest potential mechanisms for the maintenance of mitochondrial ultrastructure.