Development of wafer-scale multifunctional nanophotonic neural probes for brain 
activity mapping

Chen, Fu Der; Sharma, Ankita; Roszko, David A.; Xue, Tianyuan; Mu, Xin; Luo, Xianshu; Chua, Hongyao; Lo, Patrick Guo-Qiang; Sacher, Wesley D.; Poon, Joyce K. S.

doi:10.1039/D3LC00931A

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Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping

MPS-Authors

/persons/resource/persons260636

Chen, Fu Der
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons269799

Sharma, Ankita
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons298026

Roszko, David A.
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons277233

Xue, Tianyuan
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons265928

Mu, Xin
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons258003

Sacher, Wesley D.
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

/persons/resource/persons257612

Poon, Joyce K. S.
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

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https://doi.org/10.1039/D3LC00931A
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Citation

Chen, F. D., Sharma, A., Roszko, D. A., Xue, T., Mu, X., Luo, X., et al. (2024). Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping. Lab on a Chip. doi:10.1039/D3LC00931A.

Cite as: https://hdl.handle.net/21.11116/0000-000F-3A35-5

Abstract

Optical techniques, such as optogenetic stimulation and functional fluorescence imaging, have been revolutionary for neuroscience by enabling neural circuit analysis with cell-type specificity. To probe deep brain regions, implantable light sources are crucial. Silicon photonics, commonly used for data communications, shows great promise in creating implantable devices with complex optical systems in a compact form factor compatible with high volume manufacturing practices. This article reviews recent developments of wafer-scale multifunctional nanophotonic neural probes. The probes can be realized on 200 or 300 mm wafers in commercial foundries and integrate light emitters for photostimulation, microelectrodes for electrophysiological recording, and microfluidic channels for chemical delivery and sampling. By integrating active optical devices to the probes, denser emitter arrays, enhanced on-chip biosensing, and increased ease of use may be realized. Silicon photonics technology makes possible highly versatile implantable neural probes that can transform neuroscience experiments.