Glutamate Metabolism Mapping after Oral Administration of 1-13C-Glc using 1H 
MRSI in the human brain at 9.4 T

Ziegs, T; Ruhm, L; Wright, AM; Henning, A

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Glutamate Metabolism Mapping after Oral Administration of 1-13C-Glc using 1H MRSI in the human brain at 9.4 T

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Ziegs, T
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Ruhm, L
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Wright, AM
Institutional Guests, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://submissions.mirasmart.com/ISMRM2022/itinerary/ConferenceMatrixEventDetail.aspx?id=452
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引用

Ziegs, T., Ruhm, L., Wright, A., & Henning, A. (2022). Glutamate Metabolism Mapping after Oral Administration of 1-13C-Glc using 1H MRSI in the human brain at 9.4 T. Poster presented at Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting (ISMRM 2022), London, UK.

引用: https://hdl.handle.net/21.11116/0000-000A-5DA3-6

要旨

Glutamate is the major excitatory neurotransmitter in the brain and malfunction of glutamatergic metabolism is associated with various neurological disorders. Respective metabolic rates can be determined via direct 13C or indirect 1H-[13C] MRS after intake of 13C labelled tracers. In this work, labeling effects after oral intake of [13C-1]glucose are observed in human brain using a 1H-FID-MRSI sequence at 9.4T. Spectral time series of GM and WM voxels as well as metabolite maps show regionally distinct and tissue type specific labelling induced changes of Glu and Gln spectral pattern that allow for the determination of 13C label uptake rates.