Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora
Апстракт
A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1[N-[1(ethoxycarbonyl-3- phenylpropyl-L-alanyl]-L-proline, Lisinopril - (S) - 1-[N-2-(carboxy-3-phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]], -2- [2-[[1(-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-iso-quinoline-carboxylic acid, Ramipril- [2S[1[R*(R*)],2 alpha 3a beta ,6a beta]]-1[2[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]-pyrole-2-carboxylic acid and Cilazapril - [1S-[1 alpha ,9 alpha (R*)]]- 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino] octahydro-10-oxo-6H-pyridazino[1,2-a][1,2] diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For th...eir chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used.
U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
Кључне речи:
thin-layer chromatography / silica gel / silica gel / polyacrylonitrile sorbent / polyacrylonitrile sorbent / antihypertensive drugs / antihypertensive drugs / angiotensin converting enzyme inhibitors / angiotensin converting enzyme inhibitorsИзвор:
Journal of the Serbian Chemical Society, 2001, 66, 1, 39-44Издавач:
- Serbian Chemical Soc, Belgrade
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aleksic, MB AU - Agbaba, Danica G. AU - Baošić, Rada AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav Lj. PY - 2001 UR - https://cherry.chem.bg.ac.rs/handle/123456789/448 AB - A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1[N-[1(ethoxycarbonyl-3- phenylpropyl-L-alanyl]-L-proline, Lisinopril - (S) - 1-[N-2-(carboxy-3-phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]], -2- [2-[[1(-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-iso-quinoline-carboxylic acid, Ramipril- [2S[1[R*(R*)],2 alpha 3a beta ,6a beta]]-1[2[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]-pyrole-2-carboxylic acid and Cilazapril - [1S-[1 alpha ,9 alpha (R*)]]- 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino] octahydro-10-oxo-6H-pyridazino[1,2-a][1,2] diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used. AB - U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors T1 - Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora VL - 66 IS - 1 SP - 39 EP - 44 UR - https://hdl.handle.net/21.15107/rcub_cherry_448 ER -
@article{ author = "Aleksic, MB and Agbaba, Danica G. and Baošić, Rada and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.", year = "2001", abstract = "A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1[N-[1(ethoxycarbonyl-3- phenylpropyl-L-alanyl]-L-proline, Lisinopril - (S) - 1-[N-2-(carboxy-3-phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]], -2- [2-[[1(-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-iso-quinoline-carboxylic acid, Ramipril- [2S[1[R*(R*)],2 alpha 3a beta ,6a beta]]-1[2[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]-pyrole-2-carboxylic acid and Cilazapril - [1S-[1 alpha ,9 alpha (R*)]]- 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino] octahydro-10-oxo-6H-pyridazino[1,2-a][1,2] diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used., U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors, Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora", volume = "66", number = "1", pages = "39-44", url = "https://hdl.handle.net/21.15107/rcub_cherry_448" }
Aleksic, M., Agbaba, D. G., Baošić, R., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2001). Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 66(1), 39-44. https://hdl.handle.net/21.15107/rcub_cherry_448
Aleksic M, Agbaba DG, Baošić R, Milojković-Opsenica D, Tešić ŽL. Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society. 2001;66(1):39-44. https://hdl.handle.net/21.15107/rcub_cherry_448 .
Aleksic, MB, Agbaba, Danica G., Baošić, Rada, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors" in Journal of the Serbian Chemical Society, 66, no. 1 (2001):39-44, https://hdl.handle.net/21.15107/rcub_cherry_448 .