Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum
Нема приказа
Аутори
Jankovic, S.M.Beleslin, D.
Ivanović, Milovan
Kouvelas, D.
Argyriou, A.
Đorđević, S.
Mirtsou-Fidani, V.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable.
Кључне речи:
Analogues / Fentanyl / Ileum / RatИзвор:
Archives of Gastroenterohepatology, 1997, 16, 2, 29-32Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jankovic, S.M. AU - Beleslin, D. AU - Ivanović, Milovan AU - Kouvelas, D. AU - Argyriou, A. AU - Đorđević, S. AU - Mirtsou-Fidani, V. PY - 1997 UR - https://cherry.chem.bg.ac.rs/handle/123456789/45 AB - Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable. T2 - Archives of Gastroenterohepatology T1 - Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum VL - 16 IS - 2 SP - 29 EP - 32 UR - https://hdl.handle.net/21.15107/rcub_cherry_45 ER -
@article{ author = "Jankovic, S.M. and Beleslin, D. and Ivanović, Milovan and Kouvelas, D. and Argyriou, A. and Đorđević, S. and Mirtsou-Fidani, V.", year = "1997", abstract = "Opiates inhibit electrically-stimulated contractions of isolated rat ileum acting on δ-receptors. We have examined effects of fentanyl and its three analogues on contractions of isolated rat ileum stimulated by electric field (20 V, 22 ms, 1 Hz). Fentanyl (from 10-9 M to 10-7 M) and trans-3-(carbomethoxy) fentanyl (from 10-7 M to 10-5 M) produced concentration-dependent decrease in amplitude of stimulated contractions, only fentanyl was about 40 times more potent. Cis-3-(methyl) fentanyl and Cis-3-(carbomethoxy) fentanyl did not affect stimulated contractions. Our study suggested that introduction of methyl and carbomethoxy moieties on position 3 of piperidine ring produced loss of fentanyl activity on δ-opioid receptors, cis-orientation being specially uafavourable.", journal = "Archives of Gastroenterohepatology", title = "Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum", volume = "16", number = "2", pages = "29-32", url = "https://hdl.handle.net/21.15107/rcub_cherry_45" }
Jankovic, S.M., Beleslin, D., Ivanović, M., Kouvelas, D., Argyriou, A., Đorđević, S.,& Mirtsou-Fidani, V.. (1997). Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum. in Archives of Gastroenterohepatology, 16(2), 29-32. https://hdl.handle.net/21.15107/rcub_cherry_45
Jankovic S, Beleslin D, Ivanović M, Kouvelas D, Argyriou A, Đorđević S, Mirtsou-Fidani V. Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum. in Archives of Gastroenterohepatology. 1997;16(2):29-32. https://hdl.handle.net/21.15107/rcub_cherry_45 .
Jankovic, S.M., Beleslin, D., Ivanović, Milovan, Kouvelas, D., Argyriou, A., Đorđević, S., Mirtsou-Fidani, V., "Effects of fentanyl and its analogs on electric field-stimulated contractions of rat ileum" in Archives of Gastroenterohepatology, 16, no. 2 (1997):29-32, https://hdl.handle.net/21.15107/rcub_cherry_45 .