Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits
Апстракт
The results obtained up to now indicate that increased intake of some heavy metals causes disorder of bioelements metabolism leading to their blood and organs decrease and higher elimination via the urine. As to lead and magnesium, our investigations indicated that the reaction is reversible and that increased intake of Mg eliminates Pb via urine. Some other findings suggest similar relations between Mg and certain heavy metals, thus pointing to significant role of Mg in toxicology of heavy metals and announcing a new chapter in the toxicology of metals entitled 'Mg in professional and ecotoxicology'. In this report we present the results of our investigations on the effect of Cd on Mg metabolism. The experiment was performed on rabbits given orally, every day, for 4 weeks 10 mg Cd/kg b.w. as aqueous solution of CdCl 2 . Magnesium content was determined in blood, urine, soft tissues and bones by the AAS method. Under the experimental conditions, Cd lead to statistically significant dec...rease of blood Mg (p < 0.001 after day 16) which was associated with increased Mg elimination via urine (p < 0.01). Statistically significant changes were not detected in the tissues, except in the liver where we found enhanced Mg content (p < 0.05), while its level in the muscles decreased (p < 0.01).
Кључне речи:
Blood / Cadmium / Magnesium / Organs / Rabbits / UrineИзвор:
Magnesium Research, 1998, 11, 4, 283-288Издавач:
- John Libbey Eurotext
Институција/група
PharmacyTY - JOUR AU - Soldatović, Danilo AU - Matović, Vesna AU - Vujanović, Dragana AU - Stojanović, Z PY - 1998 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/211 AB - The results obtained up to now indicate that increased intake of some heavy metals causes disorder of bioelements metabolism leading to their blood and organs decrease and higher elimination via the urine. As to lead and magnesium, our investigations indicated that the reaction is reversible and that increased intake of Mg eliminates Pb via urine. Some other findings suggest similar relations between Mg and certain heavy metals, thus pointing to significant role of Mg in toxicology of heavy metals and announcing a new chapter in the toxicology of metals entitled 'Mg in professional and ecotoxicology'. In this report we present the results of our investigations on the effect of Cd on Mg metabolism. The experiment was performed on rabbits given orally, every day, for 4 weeks 10 mg Cd/kg b.w. as aqueous solution of CdCl 2 . Magnesium content was determined in blood, urine, soft tissues and bones by the AAS method. Under the experimental conditions, Cd lead to statistically significant decrease of blood Mg (p < 0.001 after day 16) which was associated with increased Mg elimination via urine (p < 0.01). Statistically significant changes were not detected in the tissues, except in the liver where we found enhanced Mg content (p < 0.05), while its level in the muscles decreased (p < 0.01). PB - John Libbey Eurotext T2 - Magnesium Research T1 - Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits VL - 11 IS - 4 SP - 283 EP - 288 UR - https://hdl.handle.net/21.15107/rcub_farfar_211 ER -
@article{ author = "Soldatović, Danilo and Matović, Vesna and Vujanović, Dragana and Stojanović, Z", year = "1998", abstract = "The results obtained up to now indicate that increased intake of some heavy metals causes disorder of bioelements metabolism leading to their blood and organs decrease and higher elimination via the urine. As to lead and magnesium, our investigations indicated that the reaction is reversible and that increased intake of Mg eliminates Pb via urine. Some other findings suggest similar relations between Mg and certain heavy metals, thus pointing to significant role of Mg in toxicology of heavy metals and announcing a new chapter in the toxicology of metals entitled 'Mg in professional and ecotoxicology'. In this report we present the results of our investigations on the effect of Cd on Mg metabolism. The experiment was performed on rabbits given orally, every day, for 4 weeks 10 mg Cd/kg b.w. as aqueous solution of CdCl 2 . Magnesium content was determined in blood, urine, soft tissues and bones by the AAS method. Under the experimental conditions, Cd lead to statistically significant decrease of blood Mg (p < 0.001 after day 16) which was associated with increased Mg elimination via urine (p < 0.01). Statistically significant changes were not detected in the tissues, except in the liver where we found enhanced Mg content (p < 0.05), while its level in the muscles decreased (p < 0.01).", publisher = "John Libbey Eurotext", journal = "Magnesium Research", title = "Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits", volume = "11", number = "4", pages = "283-288", url = "https://hdl.handle.net/21.15107/rcub_farfar_211" }
Soldatović, D., Matović, V., Vujanović, D.,& Stojanović, Z.. (1998). Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits. in Magnesium Research John Libbey Eurotext., 11(4), 283-288. https://hdl.handle.net/21.15107/rcub_farfar_211
Soldatović D, Matović V, Vujanović D, Stojanović Z. Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits. in Magnesium Research. 1998;11(4):283-288. https://hdl.handle.net/21.15107/rcub_farfar_211 .
Soldatović, Danilo, Matović, Vesna, Vujanović, Dragana, Stojanović, Z, "Contribution to interaction between magnesium and toxic metals: The effect of prolonged cadmium intoxication on magnesium metabolism in rabbits" in Magnesium Research, 11, no. 4 (1998):283-288, https://hdl.handle.net/21.15107/rcub_farfar_211 .