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Manufacturability, mechanical properties, mass-transport properties and biocompatibility of triply periodic minimal surface (TPMS) porous scaffolds fabricated by selective laser melting
journal contribution
posted on 2020-08-10, 14:50 authored by Shuai Ma, Qian Tang, Xiaoxiao Han, Qixiang Feng, Jun Song, Rossitza Setchi, Ying Liu, Yang LiuYang Liu, Athanasios GoulasAthanasios Goulas, Daniel EngstromDaniel Engstrom, Yau TseYau Tse, Ni ZhenSelective laser melting is a promising additive manufacturing technology for
manufacturing porous metallic bone scaffolds. Bone repair requires scaffolds that
meet various mechanical and biological requirements. This paper addresses this
challenge by comprehensively studying the performance of porous scaffolds. The
main novelty is exploring scaffolds with different porosities, verifying various aspects
of their performance and revealing the effect of their permeability on cell growth.
This study evaluates the manufacturability, mechanical behaviour, permeability and
biocompatibility of gyroid scaffolds. In simulations, mechanical behaviour and
permeability exhibited up to 56% and 73% accuracy, respectively, compared to the
experimental data. The compression and permeability experiments showed that the
elastic modulus and the permeability of the scaffolds were both in the range of human
bones. The morphological experiment showed that manufacturing accuracy increased
with greater designed porosity, while the in vitro experiments revealed that
permeability played the main role in cell proliferation. The significance of this work is
improving the understanding of the effect of design parameters on the mechanical
properties, permeability and cell growth of the scaffolds, which will enable the design
of porous bone scaffolds with better bone-repair effects.
Funding
National Natural Science Foundation of China (Grant No: 51975073, No. 51805052)
Fundamental Research Funds for the Central Universities (No. 2018CDXYJX0019)
Chongqing Science and Technology Bureau (No. cstc2018 jszx-cyzdX0102)
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
- Mechanical, Electrical and Manufacturing Engineering
Department
- Materials
Published in
Materials & DesignVolume
195Publisher
Elsevier BVVersion
- VoR (Version of Record)
Rights holder
© The AuthorsPublisher statement
This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2020-08-03Publication date
2020-08-05Copyright date
2020ISSN
0264-1275Publisher version
Language
- en