ChemPhotoChem - 2021 - Grantham - Dimeric Cyclobutane Formation Under Continuous Flow Conditions Using.pdf (4.84 MB)
Dimeric cyclobutane formation under continuous flow conditions using organophotoredox‐catalysed [2+2] cycloaddition
journal contribution
posted on 2021-12-17, 13:26 authored by Helena Grantham, Marc KimberMarc KimberRadical-cation-initiated dimerization of electron rich alkenes is an expedient method for the synthesis of cyclobutanes. By merging organophotoredox catalysis and continuous flow technology, a batch versus continuous flow study has been performed providing a convenient synthetic route to an important carbazole cyclobutane material dimer 1,2-trans-dicarbazylcyclobutane (t-DCzCB) using only 0.1 mol % of an organophotoredox catalyst. The scope of this methodology was explored giving a new class of functional materials, as well as an improved synthetic route to styrene-based lignan dimeric natural products. The cyclobutane dimers could be isolated in higher chemical yields under continuous flow conditions and reaction times were reduced significantly compared to traditional batch reaction conditions.
Funding
DTP 2016-2017 Loughborough University
Engineering and Physical Sciences Research Council
Find out more...DTP 2018-19 Loughborough University
Engineering and Physical Sciences Research Council
Find out more...Loughborough University (HFG)
History
School
- Science
Department
- Chemistry
Published in
ChemPhotoChemVolume
6Issue
4Publisher
WileyVersion
- VoR (Version of Record)
Rights holder
© The authorsPublisher statement
This is an Open Access Article. It is published by Wiley under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2021-11-25Publication date
2021-12-07Copyright date
2021ISSN
2367-0932eISSN
2367-0932Publisher version
Language
- en
Depositor
Dr Marc Kimber. Deposit date: 17 December 2021Article number
e202100273Usage metrics
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