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New routes towards reutericyclin analogues

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posted on 2015-07-28, 07:51 authored by Ray Jones, James P. Bullous, Ching-Man (Carole) Law, Mark ElsegoodMark Elsegood
A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-5 acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for their antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.

History

School

  • Science

Department

  • Chemistry

Published in

CHEMICAL COMMUNICATIONS

Volume

50

Issue

13

Pages

1588 - 1590 (3)

Citation

JONES, R.C.F. ... et al, 2014. New routes towards reutericyclin analogues. Chemical Communications, 50 (13), pp.1588-1590

Publisher

© Royal Society of Chemistry

Version

  • SMUR (Submitted Manuscript Under Review)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2014

Notes

This paper was submitted for publication in the journal Chemical Communications. The definitive version can be found at: http://dx.doi.org/10.1039/c3cc47867j

ISSN

1359-7345

Language

  • en

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