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Acute high-intensity interval rowing increases thrombin generation in healthy men
journal contribution
posted on 2016-04-22, 15:01 authored by Matthew J. Sedgwick, Matthew Thompson, Jack O. Garnham, Alice ThackrayAlice Thackray, Laura BarrettLaura Barrett, Matthew Powis, David StenselDavid StenselPurpose High-intensity exercise induces several health
benefits, but may acutely and transiently increase the risk
of cardiovascular events due to thrombotic changes promoting
blood coagulation and thrombin formation. This study
examined the effects of high-intensity exercise on plasma
thrombin generation and triacylglycerol concentrations.
Methods Sixteen healthy men completed two, 2-day conditions
separated by 1 week. On day 1, participants rested
(control) or completed four, 3-min high-intensity rowing
intervals at an average rating of perceived exertion of 17
(exercise). Venous blood samples were collected pre- and
post-intervention to determine plasma thrombin generation.
On day 2, participants rested and consumed a glucose load
(0 h) and high-fat meal (2 h). Fifteen venous blood samples
were collected between 0 and 8 h to measure plasma
thrombin generation and triacylglycerol concentrations.
Results On day 1, lag time was shorter and peak thrombin
and endogenous thrombin potential were greater in
the exercise than control condition (ES ≥ 0.37, main
effect condition P ≤ 0.03), and post-intervention compared
with pre-intervention (ES ≥ 0.49, main effect time
P ≤ 0.003). The magnitude of the post-intervention change was greater in the exercise than control condition for all
thrombin generation parameters (condition by time interaction
P ≤ 0.05). On day 2, no differences in postprandial
thrombin generation parameters were seen between conditions
(P ≥ 0.21). The total area under the curve for triacylglycerol
was lower in the exercise than control condition
(ES = 0.34, P = 0.02).
Conclusion An acute bout of high-intensity interval
rowing increased plasma thrombin generation immediately
after exercise, but these differences were eliminated
16–24 h after exercise.
Funding
The research was supported by the National Institute for Health Research (NIHR) Diet, Lifestyle and Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University.
History
School
- Sport, Exercise and Health Sciences
Published in
European Journal of Applied PhysiologyCitation
SEDGWICK, M.J. ... et al, 2016. Acute high-intensity interval rowing increases thrombin generation in healthy men. European Journal of Applied Physiology, 116 (6), pp. 1139-1148.Publisher
Springer Verlag / © The AuthorsVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2016-03-22Publication date
2016Notes
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ISSN
1439-6327Publisher version
Language
- en