Micro-RNA family that modulates fibrosis and uses thereof

Access full-text files

Date

2017-08-01

Authors

Olson, Eric N.
van Rooij, Eva

Journal Title

Journal ISSN

Volume Title

Publisher

United States Patent and Trademark Office

Abstract

The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.

Description

Keywords

LCSH Subject Headings

Citation