Administration of kynurenine depleting enzymes for tumor therapy
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Date
2018-05-22
Authors
George M. Georgiou
Everett Stone
Wei-Cheng Lu
John Blazeck
Nicholas Marshall
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.