Influenza A virus vaccines and inhibitors
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Date
2010-05-04
Authors
Edward C. Arnold
Robert M. Krug
Karen Y. Twu
Gaetano T. Montelione
Kalyan Kumar Das
Li-Chung Ma
Rong Xiao
Rei-Lin Kuo
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.